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In turn, the unbound head domain diffuses towards the proceeding direction, directed by the swinging of the lever arm from its down conformation to the up conformation.
In turn, this powerstroke moves the cargo in the proceeding direction, and at the same time facilitates the other ("moving") protomer to overcome an energy barrier in its rear-to-lead transition (i.e., dissociation from the microtubule).
Second, in the subsequent actin− state, the lever arm of myosin is released from a high-energy (i.e., unstable in the absence of actin) "up" conformation, and the associated head domain is free to search for the next binding site on the F-actin in the proceeding direction, supported by a biased Brownian mechanism (Sweeney and Houdusse 2010).
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"What we want to do is find the most effective, least expensive and least provocative way of proceeding in this direction," he said.
To his credit, Prime Minister David Cameron seems opposed to proceeding in that direction.
However, instead of proceeding in the direction of Italy, the convoy rambled interminably northward into the heart of the steppe.
The Norwalk and Greenwich Symphonies, both with opening nights on Oct. 14, are proceeding under the direction of long-standing, popular conductors.
"After all, this investigation has been proceeding under his direction and control for some time," Mr. Michelen said.
Once in place, the network no longer needed Bin Laden and, in fact, has been proceeding with minimal direction from him for several years.
It is motivated proceeding in this direction as follows.
We motivate proceeding in this direction as follows: consider Theorem 1, and let I : = { i ∈ { 1, …, n } ∣ p i ≠ 0 }.
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CEO of Professional Science Editing for Scientists @ prosciediting.com