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Given that human and mouse CYP1A1 and CYP1A2 orthologs differ in the rates of metabolism of xenobiotics, Nebert and colleagues proceeded in the generation of a "humanized" hCYP1A1_CYP1A2_Cyp1a1/1a2 mouse line.
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For IBM Syn10, j = 12 and i = 1, because only one generation proceeded in the process of double-haploid development.
Dose escalation proceeded in the absence of observed DLTs.
Consequently, reactions mediated by these oxidants have a propensity to be stereospecific, and the oxidations proceed without the generation of strongly acidic or basic byproducts.
The insertion reactions ('b') probably proceed via deprotonation, resulting in the generation of a nucleophile (−XR) which can attack the generated salt giving the impression of a H-X insertion.
This process is entirely different from the process in Western history, during which the emergence of civil societies proceed the generation of markets and the construction of the states.
Since Rest is known to be a repressor of neuronal gene expression and has been implicated in neurogenesis, we proceeded to examine the role of Rest in the generation of neurons from NSCs by assessing the expression of early and late neuronal markers (Fig. 1A).
To explore whether supercoil unwinding proceeds through the generation of topoisomer intermediates, we extended the relaxation experiments to MCs that contained increasing numbers of supercoils.
This would lead to the formation of a dimer, a key step in the generation of amyloid fibrils (Refs 72, 73), which is thought to proceed through an ordered polymerisation of β structures (Ref. 74).
Irradiation of 1 a using the higher-energy light resulted in the generation of the higher singlet excited state with τ≤25 fs, from which intersystem crossing proceeded to give the higher triplet state (HES(1)).
Hydrogen oxidation can proceed aerobically in which electrons withdrawn from hydrogen reduce oxygen to water via a series of cytochromes resulting in the generation of a proton motif force for energy transduction.
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