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The final asymmetric reductive monoamination of diketone 3a proceeded with perfect regio- and stereoselectivity at full conversions.
Using Pd PPh3)4 as the catalyst, the reaction of carbonate 524 with arylboronic acids proceeds with perfect invertive transfer of chirality to furnish allene 525 (Scheme 57 ).
"As states proceed with waivers, we can't let the perfect become the enemy of the good," Duncan said in his prepared remarks.
So proceed with caution.
Still, proceed with caution.
And finally, proceed with humility.
We must proceed with caution".
Yellow, proceed with caution.
Amber usually means proceed with caution.
Lots of spoilers, so proceed with caution.
Then proceed with the recipe.
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