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Only high-impact papers proceed to validation.
Clearly, if putative hits at the bead level must be resynthesized and purified to proceed to validation studies, a huge amount of effort would be wasted on compounds that ultimately prove to be of little value.
Based on these two calls, the ClinLabGeneticist will take the following actions for the variant based on an internally developed logic (Table 3): report and proceed to validation by Sanger sequencing, report without Sanger sequencing, or do not report.
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If a method development study exhibits highly variable results (e.g., high%RSD) or lower than desired percentage recovery values, various parameters should be assessed prior to proceeding to validation including but not limited to the following: (1) container composition; (2) protection from light; (3) temperature; (4) filter bias; (5) dosing apparatus, and (6) stability.
We point out the component models fitting to formal modeling, and proceed to the validation of all designed models through a simulation scenario based on real-world road traffic data.
Here we describe the analytical performance of the individual components of the Onco type DX Colon Cancer Assay, which allowed us to confidently proceed to clinical validation.
No mutation or variant was identified in these 48 breast cancer cases, and so we did not proceed to a validation series or further studies in breast cancer.
The purpose of our study was to create a scale to collect subjective cognitive complaints of patients suffering from schizophrenia with Tunisian Arabic dialect as mother tongue and to proceed to a validation study of this scale.
The emerging field of lipidomics faces three main analytical challenges: (i) a paucity of bioinformatic tools for spectral analysis; (ii) the need for accurate lipid prediction algorithms before experimenters can proceed to empirical validation; (iii) a requirement for visual tools capable of displaying all theoretically possible lipid conformations in 2D and 3D.
In preparing to proceed to Phase 4 validation, we developed a prediction model to stratify BE patients, validated our model, and estimated its potential clinical impact (endoscopy savings) by applying a simulation.
The complexity of determining correlated substitutions has been understated, as it is more than just an issue of selecting the "most accurate" algorithm and proceeding to experimental validation.
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