The assembly then synchronously proceeds through three subsequent functional states of the switch: Refractory, Competent, and Active, from which the rotational sense is switched again.
Therefore, intron length is the determining factor for the switch from the intron definition mechanism, in which the 5′ and 3′ splice sites are initially recognized and paired across the intron, to the exon definition mechanism, in which splice sites are paired first across the exons, with spliceosome assembly proceeding through subsequent pairing of exon units [ 141].
Hence the role of Wnt9b in the initiation of MET and the subsequent requirement for Wnt4 expression to proceed through this event is well documented [12], [13], as is the requirement for Notch2 for proximal tubule specification [14].
Nevertheless, the G-dCTP and T-dATP products after step 2.1 are able to proceed through step 2.2 (fingers closing), suggesting that there is no subsequent defect in fingers closing due to the E710A mutation.
Accordingly, cultures were synchronized in G2 and released for approximately 30 minutes to proceed through the first synchronous mitosis before treating with CPT in the subsequent S phase.
The dramatic PrP chain conformational reorganization accompanying the conversion of PrPC into PrPSc is believed to proceed through a complex pathway involving the obligatory initial destabilization of the PrPC α-fold for its subsequent refolding and assembly into PrPSc.
Microtubule inhibiting agents (MIAs) act by suppressing the dynamic instability of microtubules, and cells treated with MIAs do not proceed through mitosis because of sustained activation of the spindle checkpoint leading to prolonged mitotic arrest and subsequent apoptosis.
They proceed through copycat behaviour.
The supervision must proceed through all stages of a job.
These cellular outcomes proceed through natural cellular engineering.
