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By restricting diagnostic procedures to a minimum, and with an early start of chemotherapy, median survival has improved from 3 6 months of the past (Altman and Cadman, 1986; Alberts et al, 1989) to around 1 year in recently reported series (Briasoulis et al, 2000; Greco et al, 2000a).
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In addition, it is shown that DOE' method allows to reduce significantly the number of test measurements, and therefore to shorten the adjusting procedure to a minimum.
This is achieved by a novel parameter selection strategy that, unlike a full parametric analysis, avoids the use of objective function evaluations, thus keeping the overall computational cost of the procedure to a minimum.
The incorporation of the target PSNR transforms the optimization to a constrained procedure to ensure a minimum of image quality that must be acquired.
Surgical and sampling procedures were kept to a minimum and were conducted under anesthesia followed by appropriate analgesics for pain and discomfort, which was carefully monitored.
Variability due to fixation and staining procedures are reduced to a minimum, while comparability is maximised.
But there is surely now a strong case for setting up procedures to enforce minimum standards of accountability for countries aiming to draw from these funds.
The recommendations presented here provide a means by which all sites participating in a trial or comparative trials of novel TB vaccines, or indeed any multi-centre study where immunological monitoring by ELISpot assay is desirable, can ensure that variations due to assay procedure are kept to a minimum.
In the last gulf war, such "friendly fire" incidents accounted for a large proportion of allied casualties, and there were vows that better coordination and identification procedures would keep them to a minimum in this conflict.
Five complex surgical procedures are consequently subjected to a minimum volume standard (Table 1): liver, kidney and stem cell transplantations, and complex oesophageal and pancreatic interventions.
"Procedures are done to reduce discomfort to a minimum.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com