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The conflicting results indicate that differences in procedures, study design or investigated population may have a large impact on reproducibility estimates.
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A more detailed discussion of the recruitment procedure, study design, and data collection has been published elsewhere [ 16].
All animal procedures and study design were conducted in accordance with the Guidelines of the Institutional Animal Care and Use Committee (KRIBB-AEC-11010) in Korea Research Institute of Bioscience and Biotechnology (KRIBB).
Prior to data collection, the outcome assessors from a center for data and information management participated in a 2-hour training session on assessment procedures and study design.
Although the comparability of the samples from participating countries may be limited by some flexibility relating to recruitment procedures, the study design included the use of a standardized protocol with shared inclusion and exclusion criteria.
Recruitment procedure and study design have been described previously [ 21].
LJ contributed to the implementation of the new procedure and study design, and drafted and revised the manuscript.
Mohammad Ghalayini performed all experimental procedures, assisted in study design, data interpretation and wrote the paper.
Details on sampling procedures and the study design have been reported elsewhere (13).
Ideally, PMA provides standardization of clinical trial procedures, such as study design and data collection methods, by using, for example, the same instruments and the same time points for measuring outcomes.
The study design, procedures and informed consent procedure were approved by the Medical Ethics Committee of the University Medical Center Groningen (No. 2007.217).
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