The reaction was performed in a combustion reactor designed in the laboratory, which presents some advantages over other classical procedures (heating with a hot-plate, a furnace or a microwave oven).
In order to determine the parameters optimal for this procedure, heat transfer from plasma to the film was first modelled to evaluate melting front penetration range and liquid state duration.
Hulett calls this procedure "heat-mapping," and provides the resulting data to advertisers in real-time.
Following the general procedure, heating 5a (10 mg) for 30 min afforded the pyrazolinone 6a (3 mg, 30%) as a glassy solid.
Following the general procedure, heating 1b (14 mg) for 10 min afforded 4- prop-1′,2′-dienyl -1,3,4-triphenylpyrazolin-5-one (4- prop-1′,2′-dienyl -1,3,4-triphenylpyrazolin-5-one
Following the general procedure, heating 7a (10 mg) for 10 min afforded 6a (8 mg, 80%) with data identical with the previous reaction.
(b) Schematic illustration of direct imprint procedure: heating at low pressure, increasing pressure at fixed temperature, cooling accompanied with decreasing temperature, and releasing of pressure.
Following the general procedure, heating 2b (24 mg) for 10 min afforded 4- prop-1′,2′-dienyl -1,3,4-triphenylpyrazolin-5-one (4- prop-1′,2′-dienyl -1,3,4-triphenylpyrazolin-5-onel with 4- prop-1′,2′-dienyl -1,3,4-triphenylpyrazolin-5-one
Following the general procedure, heating 2a (20 mg) for 10 min afforded 3,4-diphenyl-1-methyl-4- prop-1′,2′-dienyl pyrazolin-5-one (4a) (18 mg, 90%) as a white solid with data identical with 4.4.1.
Following the general procedure, heating 1a (30 mg) for 60 min afforded 3,4-diphenyl-1-methyl-4- prop-1′,2′-dienyl) pyrazolin-5-one (4a) (10.5 mg, 3,4-diphenyl-1-methyl-4- prop-1′,2′-dienylC (Et2O).
