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A key finding is that existing a priori parameter estimation procedures are problematic and need improvement.
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In such cases, identifying orthologs in other mammals using the standard bi-directional best-hit procedure is problematic, since the rates of sequence evolution may vary in different lineages and genomic regions.
This decision was problematic.
The strategy is problematic.
However, traditional regression procedures are usually problematic, owing to potentially large numbers of correlated and complex variables.
Limb-sparing procedures are more problematic than in adults, and remain a challenge in very young children [ 13- 16, 32, 39].
Although vertebroplasty and KP are relatively safe and easy procedures to perform, complications from these procedures can be problematic.
Recent research on curriculum-based measurement of oral reading fluency has revealed important issues in current passage development procedures, highlighting how dissimilar passages are problematic for monitoring student progress.
She argues that the researcher who is marginalized may recognize that many of the concepts and procedures adopted by the discipline are problematic when her colleagues do not, precisely because she is able to see the objects of inquiry both with the eyes of a researcher trained in the discipline and through her own experience from a marginalized social location.
However, these procedures can be problematic in terms of cost-effectiveness, surgery time, and healing time.
The critical nature of sample handling (Banks et al, 2005), the relatively poor mass resolution of some platforms and lack of QC procedures have been problematic (Whelan et al, 2008; Findeisen and Neumaier, 2009).
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