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A complete description of data-collection procedures and analytic guidelines are available elsewhere (www.cdc.gov/nchs/nhanes.htm).htm
12– 71 The largest case-control study to date, based on 1,732 cases and 2,309 controls, was a multicenter collaborative investigation conducted in five countries using a common protocol, questionnaire, field procedures, and analytic techniques.
Discrepancies between the results of these analyses are expected since they used different data sets as a consequence of differences in their respective eligibility criteria, procedures and analytic methods.
Despite differing cohort characteristics, follow-up procedures and analytic approaches, our data are consistent with and extend previous studies that have found a poor association between CD4 cell counts and the development of virological failure [ 8, 15].
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All other experimental data including chemical procedures and analytics are provided in the Supporting Information.
The details of the experimental procedure and the analytic derivation for calculation of f(a/W) are available in Ref. (Samal et al. 2010a, b; Sanyal and Samal 2012a) and briefly narrated in Appendix.
Variation caused by the capture and immobilisation procedure (stress, helicopter pursuit and anaesthetics), blood collection, and analytic procedures may affect the results, but are an inherent challenge in studies involving free ranging animals.
Studies interested in measuring environmental chemicals should avoid, if at all possible, the use of preservatives that may interfere with analytic procedures, and should provide collection protocols to the analytic laboratory in advance so potential interferences can be anticipated.
However, there remain huge ambiguities in its definitions, implications, particularly measurable indicators, and analytic procedures.
Here comment is made on the fashion in which research design and analytic procedures contribute to limit the capabilities of each of the techniques presented.
From the examination conducted, the authors suggest that published articles representing this body of research frequently provide inadequate detail of the methodological and analytic procedures utilized.
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