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For these patients, results for the catheter based procedure were imputed, and were mostly positive (range 65-77% across imputations), which accords with a reduced positive predictive value of the CT based procedure.
Although data for the catheter based procedure were imputed for a large proportion of patients, we believe that the high sensitivity and specificity of the CT based procedure justifies the imputation; we also did not consider the CT based procedure as an explanatory variable in the prediction models.
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Using the Markov Chain Monte Carlo method from the SAS MI procedure 20 datasets were imputed.
Missing data were imputed using multiple imputation procedures.
Missing data were imputed with multiple imputation procedures using NORM, version 2, software (32).
Therefore, missing values were imputed using a multiple imputation procedure following the approach of van Buuren and Groothuis-Oudshoorn, 33 resulting in five imputed data sets.
From this point on, the procedure varied depending on whether missing values were imputed under a single or nested imputation method.
Missing exposure data were imputed with a multiple imputation algorithm (SAS MI procedure, version 9.2; SAS Institute Inc., Cary, NC) based on the exposure data for all eligible persons (n = 2,222), creating 18 replicate imputed data sets.
Missing values for specific PAH compounds were imputed following standard procedures (Little and Rubin 2002).
13 14 Missing values for relapse date were imputed using the procedures described above.
Missing BDI-II and BAI values were imputed by means of a multiple imputation procedure [ 43] using the automatic method in SPSS 21.0.
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