To accelerate the logical drug design procedure, we created the program "NAGARA," a plugin for PyMOL, and applied it to the discovery of small compounds called medical chaperones (MCs) that stabilize the cellular form of a prion protein (PrPC).
With this procedure, we created 100 independent datasets.
To further test the alignment procedure we created virtual 'ground truth trajectories' from which we generated sets of virtual trajectories by adding different levels of random noise.
To test how robust the signals identified by SVD are, we performed the following procedure: we created ten subsets containing 80% of the data, then computed the pairwise correlation between the signals identified for each of the 10 data subsets.
To verify the accuracy of Solexa and the normalization procedure, we created three replicate dilution series using genomic DNA from the tester line and an experimental line (W line 84).
Therefore, for each SRE, with the exception of BS (since claims for this were clearly indicative of a bone surgical procedure), we created two lists of ICD-9-CM and HCPCS codes that indicated the presence of that SRE subtype.
To increase the speed of these procedures, we create two binary tree indices on the node table; one on the sub, start and stop position of each range, and one on the start and stop values only.
Following previously accepted mixing procedures, we created water accumulated fractions (WAF) of Macondo oil with autoclaved E3 embryo medium [ 40, 123].
In a two-step selective coding procedure, we first created a system of categories describing the meanings and attitudes related to employment and family formation abstracting codes from the individual cases.
For the mapping between the ontologies of our approach, we create a procedure that corresponds to the previous definition.
