To mitigate this problem and to assess the stability of the cutoff value for each measure as well as the combined score, and, more importantly, to deal with the greatly uneven positive/negative set sizes, we have adopted an undersampling procedure for the negative sets.
The usual procedure is enlargement: the negative is projected onto a sensitive paper carrying a silver halide emulsion similar to that used for the film.
We further introduce the post-smoothing procedure to avoid the negative volume of elements.
Bias may come from a non-convincing sham procedure, or from the negative effect of being included in a "psychological", or in a non-treated control group.
Since the pioneering work of Edmonston (p. 569 in [7]), several procedures remove the negatives that come with the commodity technology model.
The same procedure was used for the negative controls except that the primary antibodies were omitted resulting in no staining in the tissue except for auto-fluorescence in the internal elastic lamina.
The same procedure was followed for the negative control but in the absence of the primary antibody.
The sense RNA was prepared by a similar procedure and used as the negative control.
The check procedure contributes most to the negative relationship between age of the patient and TOP compliance, this check is more often skipped when an older patient is involved.
