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In order to speed up the docking procedure, the multi-mer was simplified by removing the redundant chains A and B. The receptor preparation was completed by the manual removal of all waters, the ligand molecule and the ADPs of the other binding site formed by chain C and D. The selected drug candidates were prepared using Ligprep 2.5.
At the end of this procedure, the multi-well plate had cells grown in fresh medium for different amounts of time post inoculation, ranging from zero to 15 hours.
To alleviate the computational burden of the procedure, the multi-parametric sensitivity analysis has been limited to the parameters subset Θ:={ k1, k2, k5, k7, k8, k9, μ13, μ16, μ17}, which, according to the local sensitivity analysis, have a major influence on the system dynamics (see Figure 4).
Second, using multiple-shooting as the local search procedure reduces the multi-modality of the non-linear optimization problem significantly.
The MIM procedure of Multi-QTL allows the appropriate model to be attributed to each LG.
The design procedure for multi-synchronization through output feedback strategy is described and the sufficient condition is given.
Algorithmically, strong or weak anchor points are treated by DIALIGN in the same way as fragments (= segment pairs) in the greedy procedure for multi-alignment.
In view of the analytic results for multi-HRS during reset procedure, the carrier transport mechanism is understood to be converted from Ohmic conduction to Schottky emission.
This paper considers the optimization procedures of multi tuned mass damper (MTMD) systems.
The data extraction procedure with the proposed multi-microphone technique is described in this section.
The multi-criteria optimization procedure is utilized in order to calculate the primary controller settings which subsequently define the vibro-isolation characteristics of active suspensions.
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