As could be expected (the behavior being routinely observed for stereovision-based reconstruction procedures), the error in the direction (i.e., range) is much higher than that in the and directions (corresponding approximately to the directions of the coordinate axes of the image plane).
The normalization procedure decreased the error in the fitting procedure due to the variation in CYP3A expression, interpreted as the variation of apparent Vmax between studies.
Furthermore, it is a highly scalable classification algorithm, eliminating the need for separate cross validation and error estimation, as these procedures are part of the internal classification routine (for details on the procedure and the error estimates we refer to Additional file 1).
The assessment of the tissue specificity of the molecular signatures obtained with the BVS procedure has been performed using a cross-validation procedure for the error estimation as described in [56].
The paper provides details about the algorithms for the localization and the measurement of the required quantities, as well as the calibration procedure and the error correction.
The red triangles represent the average number of components derived from multiple repetitions of the measurement procedure and the error bars indicate the standard deviation.
A LOO procedure estimates the error by training the classifier on all but one individual; this individual is used for testing.
Statistical analysis was conducted using R (version 3.0.0) and the SAS (version 9.3) GLIMMIX procedure, and the error in covariates sensitivity analysis was conducted using WinBUGS; the code is available from the authors by request.
Within each cross-validation iteration, the best parameter value is determined based on an inner cross-validation procedure and the error rate is then computed for this parameter value.
Based on the emergency operation procedure, the human error modes were identified by using systematic human error reduction and prediction approach.
