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This registration procedure previously demonstrated excellent intra- and inter-reader correlations [ 23].
The positioning protocol, image processing, and registration were as formerly described [ 5, 13] This registration procedure previously demonstrated excellent intra- and inter-reader correlations [ 5].
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This procedure has been previously demonstrated to yield a high proportion of neuronal cells expressing MSN markers (e.g. 95 98% of NeuN-positive cells express high levels of DARPP-32) and exhibiting an electrophysiologic behavior characteristic of GABAergic neurons [21].
Physical activity, location, and people present were recorded across the day for each patient using established standardised behavioural mapping procedures, which have been previously demonstrated to have high interrater reliability [ 9].
The study was conducted using a previously demonstrated successful procedure (rigorous and regular follow-up calls every 2 months) [ 22, 31] in addition to the reminder note to be completed by the treating physician at the time of diagnosis of AOM, which help to limit recall bias and the dropout rate.
In this enlarged repertoire of possibilities, we have identified examples of drug repurposing (some of them were previously demonstrated experimentally), a procedure which is becoming more and more attractive thanks to the reduced costs on the preclinical and clinical steps.
The efficacy of ketorolac in decreasing postoperative pain following orthopedic surgical procedures including spine surgery has been previously demonstrated [ 12- 16].
This was also previously demonstrated during a euglycaemic clamp procedure with increasing IDegAsp doses [ 15].
This procedure ensured that blood collection did not compromise mouse survivability as previously demonstrated [3], [4].
A cleaning procedure was not included as part of this study; however, it was previously demonstrated that soil load accumulation may not significantly impact microwave generated steam decontamination of FFRs [5].
It was previously demonstrated in our laboratory that conditioned fear in humans can renew after extinction, when this procedure took place in a different context (ABA-renewal [Vansteenwegen et al. (2005).
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