The Cox model was estimated using the procedure cph of the rms package written by Frank Harrell [ 23] and on the coxph procedure of the survival package written by Terry Therneau [ 24].
However, the stressful conditions generated during the sampling process resulted in variable post-handling mortality which also provided the unplanned opportunity to evaluate the effect of field procedures on survival.
It is also well known in these older subjects that the time from transplantation to the point where subjects have an advantage from the transplant procedure in terms of survival benefits compared to wait listed but not transplanted matched subjects is almost twice as long as in younger subjects [ 27].
The procedure of screening the survival studies for eligibility, and subsequent inclusion and exclusion analysis, was identical to the procedures for the RSA studies, with the exception of inclusion and exclusion criteria.
Survival and CAV-free survival time was analyzed using the Kaplan Meier procedure and statistical comparisons of survival distributions between different categories were made using the log rank test.
Survival was estimated by the product-limit procedure of Kaplan Meier, and survival curves were compared with the log rank test.
What costs to the patient who must undergo our therapies; to the health care team, who must perform often invasive, painful procedures when the chances of survival are very poor; and to society are we all willing to accept?
I'm sure that there are many high-cost and low-success-rate procedures that are statistically unnecessary, but if one of those procedures represents the only chance of survival for a friend or relative, it will seem very necessary to me.
Interestingly, reproductive age women, age 16 40, with stage I II epithelial ovarian cancer who underwent uterine-sparing surgical procedures (n=435) had similar rates of survival compared to their counterparts (n=620) who underwent standard surgery (93.3 vs 91.5%; P=0.26).
Nevertheless, despite more favorable features of the second transplant group, it was disappointing that such patients did not experience an important prolongation of survival with the procedure.
