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The basic procedure of meta-analysis was performed as described previously [ 12- 14].
This indicates that the described procedure of meta-analysis could cope well with the high heterogeneity of the biological systems and the different microarrays used.
39 The procedures of network meta-analysis will be conducted according to the PRISMA extension statement for reporting of systematic reviews incorporating network meta-analyses of healthcare interventions.
This problem occurs in likelihood-based and method of moments estimation procedures of multivariate meta-analysis, as these estimators truncate the between-study correlations on the boundary of their parameter space [ 16, 19, 23].
We used the following procedures for meta-regression analyses.
The detailed procedure of study selection in the meta-analysis is shown in Figure 1.
Provided fast methods are used to generate the original alignment, the meta-alignment procedure of M-Coffee can use a sparse DP procedure that takes advantage of the strong agreement between the considered alignments.
There is still no available methodological procedure for a meta-analysis of regression coefficients of multivariable outcome prediction models.
We propose an eight-step procedure for better validation of meta-analytic results in systematic reviews (1) Obtain the 95% confidence intervals and the P-values from both fixed-effect and random-effects meta-analyses and report the most conservative results as the main results.
At the end of the procedure, a meta-profile is the median profile of the remaining probes.
Additional file 2: Detailed procedure of short-reads, long-reads and meta-assemblies.
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