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In the guidelines for the validation procedure of Harmonization [46], signal-to-noise ratio it is suggested to apply analytical procedures that exhibit baseline noise.
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The present paper provides a description of the cohorts included in the project, focuses on the post harmonization procedures to merge these cross-national data and describes the methodological challenges encountered in the process of harmonization.
The use of harmonization procedures (Sun et al. 2011) to reduce variability between multiple studies has allowed for more direct comparison of similar production frameworks given different assumptions.
As the first step of harmonization of procedures between laboratories, EPITARGET established working groups for designing project-tailored common data elements (CDEs) and case report forms (CRFs) to be used in data collection and analysis.
Data sharing is hindered by the lack of harmonization between the policies and procedures of research initiatives (Austin et al. 2012) and of funders.
However, the routine use of these data sources to generate nationally relevant burden estimates might be problematic, due to the lack of harmonization between databases and data collection procedures in the different Belgian regions.
The parent drug stability guidelines issued by the international conference of harmonization (ICH) [22] requires that analytical test procedure should indicate stability.
The limit of detection (LOD) and limit of quantification (LOQ) were determined according to The International Conference of Harmonization (ICH) guidelines for validation of analytical procedures [31].
To achieve this, the concept of harmonization has been proposed.
Recent experience suggests that regulatory harmonization can increase, rather than decrease, systemic risk, an effect that is the precise opposite of the objective of harmonization.
She smiled at the sound of harmonization and beatboxing.
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