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Additionally, we used the Benjamini-Hochberg procedure of false discovery rate (FDR) control for multiple testing correction.
The Benjamini-Hochberg-derived step-up procedure of False Discovery Rate (FDR) was applied to account for multiple hypothesis testing, thus to assess the significance of the biological theme enrichments.
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Raw p values were adjusted using the Bonferroni procedure for control of false discovery rate.
While our method deals to some extent with false negatives, through its edge addition procedure, the issue of false positives is not addressed.
However, the proposed track management and FTD procedures terminate majority of false tracks and the efficiency of false track termination is reflected in the execution time.
Moreover, while additional peptide fragments were found, the algorithms used in the proteomic detection procedures prevent identification of false positives.
When an extensive lymph-node dissection is performed by video-assisted mediastinal lymphadenectomy (VAMLA) or transcervical extended mediastinal lymphadenectomy (TEMLA) procedures, the rate of false negatives becomes extremely low [5 7].
The system was set-up prior to the beginning of the experimental procedure to verify absence of false signals across adjacent sensors (data not shown).
The simulation results show that even under severely varying variances, the procedure controls the number of false positive findings very well.
This procedure reduces the incidence of false positive associations, although it might also reduce power to detect true positives of exceptionally large effect.
Using SPA for performing dosage screens has limitations, as the overlap between screens shows that the procedure produced significant numbers of false positives and negatives.
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