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Two recent explorative studies in cervix cancer (weekly cisplatin plus low-dose VP16) and H/N cancer (weekly cisplatin as single agent) (submitted) revealed that the procedure of dose adaptations using DNA-adduct levels and/or AUC of cisplatin is feasible in a research setting, even when the turnaround time for reporting of analytical and pharmacokinetic results is as short as 1 week.
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The data obtained in acute toxicity test by a procedure of fixed dose suggest that the oral LD50 of HZJW in mice was over 18.0 g/kg.
These findings reinforce those reports based on small sample sizes and highlight the importance of increasing cardiologists' awareness of the regular use of radiation protection devices and the necessity of optimizing procedures for dose reduction.
Carcinogenicity testing today normally includes 2-year studies in rats and mice of both sexes, following widely accepted procedures for husbandry; selection of dose levels; pathology and toxicity observations; and statistical interpretation of tumor data.
The procedure and dose of CORT administration was performed as described in Mao et al. [ 20].
The animals were randomly divided into 3 groups, according to the instillation procedure and dose of papain used to induce emphysema.
An assessment of dose per procedure will be made when the technique is established.
Unfortunately, most of the published data are stated in terms of dose per procedure, and most of the data are for physicians rather than assistants, nurses, technologists, or other staff.
This illustrates the procedure of adjusting the daily dose to a preset target in terms of AUC0 24 h.
Implementation of the principles internationally will have two important benefits; improvement in the quality and consistency of the rodent bioassay and international harmonization of dose selection procedures.
Important considerations are differences in the strain of animal used, diet and housing practices, rigorousness of test procedures, dose selection, histopathology procedures, application of historical control data, statistical evaluations and whether statistical extrapolations are supported by, or are beyond the limits of, the data generated.
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