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In such cases, identifying orthologs in other mammals using the standard bi-directional best-hit procedure is problematic, since the rates of sequence evolution may vary in different lineages and genomic regions.
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A key finding is that existing a priori parameter estimation procedures are problematic and need improvement.
For tests with very small numbers of studies to pool (n ⩽ 4) fitting a bivariate model is problematic as the procedure frequently fails to converge.
Essentially, it takes a guess at the colour of each pixel based upon that of its neighbours.This procedure can be problematic, however.
Since the same deterministic formulation can be the limiting case of many individual based models, this procedure may be problematic.
This procedure can be problematic when analyzing microbial communities with a large proportion of so far not well-characterized phyla.
However, high abundance of secondary compounds, especially in tobacco, is problematic for chromatographic procedures.
It is difficult to make direct comparisons; defining what makes an "athlete," for example, is problematic, and police and judicial procedures vary from county to county.
Although vertebroplasty and KP are relatively safe and easy procedures to perform, complications from these procedures can be problematic.
This is problematic at best, particularly if these procedures aren't reported.
This last measure is problematic because of the ease with which the disease can be passed on if strict procedures are not followed.
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