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Evidence of recent migration events across clusters was assessed using the Bayesian multilocus genotyping procedure implemented with MCMC methods in BayesAss v.1.3 [ 22].
An alternative procedure implemented with SPIDER (Shaikh et al, 2008), which normalizes the two locally superimposed maps by matching average and standard deviation of the two maps before subtraction, resulted in the same difference density.
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The model was fit using the maximum-likelihood procedure implemented in Count, with the default null model as a starting point, and with gain, loss, and duplicate rates estimated for all branches of the tree.
We have used a yes-no procedure implemented in trials with four randomly interleaved staircases (each known as 1down-1up).
Scalp data for individual participants were transformed into the time-frequency domain from 10 to 60 Hz using the complex demodulation procedure implemented in BESA with a time-frequency sampling of 5 Hz/10 ms [see 75].
The standard procedure implemented in BeadStudio, with default parameters suggested by the platform manufacturer was used to perform Genotype calling.
Presence of null alleles at each locus and sample was tested using the procedure implemented by microchecker with a 99% confidence interval (Van Oosterhout et al. 2004).
To assess the significance of the path coefficients, we used the bootstrapping procedure implemented in Smart PLS with 1000 resamples.
All analyses were conducted with five plausible values and unified with the procedure implemented in Mplus.
Conceptually, this procedure implemented the assumption that drugs with common targets might have more similar actions than structurally similar drugs.
GoShifter was run for 10,000 permutations and enrichment P values were adjusted for multiple testing using the Benjamini and Hochberg procedure implemented in the R function p.adjust with a 5% FDR.
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