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FARNA/FARFAR (Das and Baker 2007; Das et al. 2010) models RNA 3D structures by assembling of short fragments (1 3 nucleotides) from a single crystal structure via a Monte Carlo procedure guided by a knowledge-based energy function that encodes base-stacking and base-pairing potentials.
Since the resulting robust problem can prove very challenging even for a modern state-of-the art optimization solver, we propose to solve it by an original primal heuristic that combines a probabilistic variable fixing procedure, guided by peculiar Linear Programming relaxations, with a Mixed Integer Programming heuristic, based on an exact very large neighborhood search.
While there are many possible scenarios in which correlation could play a role, the main point is that the feature-selection procedure guided by (4) automatically identifies the optimal combination of features, even in the presence of correlation.
This pruning procedure, guided by a minimal cost complexity measure, creates a nested subset of trees.
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Since 2001, the register has collected data from outpatient consultations in specialised care with a capture rate of about 50% for prostate biopsy procedures guided by transrectal ultrasound.
Our experiments provide methodology to achieve accurate Ki67-LI estimation by DIA, based on proper validation, calibration, and measurement error correction procedures, guided by quantified bias from reference values obtained by stereology grid count.
[ 48] We suggest that rigorous prospective evaluation of current and new approaches is possible and desirable with use of consent and assent procedures guided by the Mental Capacity Act 2005.
Main left soon after Solomon's arrival for a 9-month visiting research fellowship in Bielefeld with Karin and Klaus Grossmann, and in her absence, instructed Solomon to learn how to classify Strange Situation procedures, guided by feedback that Main sent back to the laboratory (Judith Solomon, personal communication, September 6 , 2012.
The application of the proposed procedure is guided by showing a running example, using data of the Wisconsin Breast Cancer Dataset.
The confrontation procedure was guided by a standardized interview manual and took place on two separate days.
The standardization and annotation procedure was guided by previous databases that combine reaction and compound data from various sources [34, 35].
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