An adaptive procedure for window length selection has been provided in [28].
Similarly, an automated procedure for window width selection is possible and will be discussed in our future study.
We discuss how we determine the (mathcal {T} ick, (mathcal {R})eport, and (mathcal {S} cope functions in the case of time windows, being the procedure for count windows analogous.
As missing values were present at 1 and 6 months due to dropout and other reasons, we performed multiple imputations with SAS 9.1.3 via procedure MI SAS Systemm for Windows, version 9.1, SAS Institute, Cary, NC).
To assess the effect of motesanib administration on erlotinib exposure with or without gemcitabine, geometric least squares means (GLSM) and the ratio of GLSM between week 3 (with motesanib) and week 2 (erlotinib alone at steady state) were calculated for Cmax and AUC0 24 using the SAS PROC MIXED procedure (SAS for Windows, version 9.1, WIN_PRO platform; SAS Institute Inc., Cary, NC).
Analysis was implemented using the MIXED procedure in SAS for Windows, Version 9.1.
Multivariable models were created by a backward stepwise procedure using Egret for windows.
The effects of age and acetaminophen treatment were analyzed using the GLM procedure (SAS 9.1 for Windows, SAS Institute Inc., Cary, NC).
Treatment effects were analyzed by least squares analysis of variance using the General Linear Models procedure of SAS SASS for Windows, version 9.3, SAS Institute Inc., Cary, NC, USA).
Statistically significant P values and CIs were corrected for multiple comparisons of infant feeding groups using the Dunnett procedure in SAS for Windows 9.1.3 (SAS Institute Inc., Cary, NC).
