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However, this is a relatively small study although this has been one of the main problems of studies on catatonia.
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Clinical research of restorative materials is confounded by problems of study designs, length of trials, type of information collected, and costs for trials, despite increasing numbers and considerable development of trials during the past 50 years.
With our set-up we could solve two main methodological problems of studying consequences of dispersal, randomization and detectability of free-living individuals.
This highlights one of the problems of studying the development trajectories of numerical competency in humans, namely the difficulty of devising experimental paradigms applicable at the same time to newborns, toddlers and infants.
However, it seems unlikely that such study will ever be performed because of logistic problems of study size and patients noncompliance.
In the following we first discuss various validity threats to our results including selection biases, problems of study design and instrumentation.
Although we identified seven studies evaluating 'teen' clinics, no conclusions could be drawn regarding the effectiveness of such clinics because of problems of study design and selection bias in the included studies.
The use of cocktails that include different antibodies as a routine test overcomes the problems of studying small lesions in prostate needle biopsies with multiple IHC stains [ 107, 108].
A main problem of studies based on self-administrated questionnaires is to correctly diagnose patients with the co-existence of two or more headaches, usually migraine and tension-type headache.
A major problem of studies of autism to date has been the inability of one study to replicate the biological markers found in another study.
Research on how to evaluate computer innovations in learning highlights the problem of studies across different modes of instruction, such as the present one [ 20, 21].
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