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In order to overcome the problems of donor site pain, allograft and bone substitutes have gained increasing interest (Sandhu et al. 1999, Ehrler and Vaccaro 2000).
This would negate the need for sourcing autologous cells, for example, from adipose tissue or bone marrow, which have associated problems of donor site morbidity and limited cell number.
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Gastrocnemius musculocutaneous flaps have been widely used for complex knee-defect reconstruction, but problems of donor-site morbidity and bulkiness of flaps remain.
However, there is little information about renal disease, social and psychological problems of donors after donation.
Human tissue and organs good enough to be used for transplants could soon be made using a custom-designed 3D "bioprinter" that would help solve the problem of donor shortages.
All donor sites were closed primarily without the need for skin grafting, negating the problem of donor site morbidity that is associated with skin graft harvesting.
The problem of donor scarcity has led to the recent development of tissue engineering technologies, which aim to create implantable tissue equivalents for clinical transplantation.
Mesenchymal stromal cells (hMSCs) are advancing into the clinic but the therapeutic efficacy of hMSCs faces the problem of donor variability.
Even though it is still at an infancy stage, these studies may hold promise for generation of specific functional organs for organ transplantation, to help solve the clinical problem of donor shortage.
"There are other tools and I think this highlights the problem of donors giving simply because of a celebrity affiliated with the charity," she told Marketplace.org.org
The use of hepatocytes does, however, not solve the problem of donor-shortage.
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