In particular, protein drugs are subject to immune surveillance in the human body, and ensuing antidrug immune responses can cause a wide range of problems including altered pharmacokinetics, loss of efficacy, and even life-threating complications.
A bolt of altered perspective.
However cognitive impairment on visual-perceptual and spatial processing tasks may be related to increased risk of social problems and altered interpersonal relationships.
Multi-objectivization means that helper objectives are added to an optimization problem with the purpose of altering the search space in a way that improves the progress of the optimization algorithm.
To get a bit of perspective on this, imagine the whole population of England uprooting and moving to India, causing all manner of problems, and altering the course of India's path like something out of a Thomas Pynchon novel.
The intensive computation inherent in these problems has altered the course of methodological developments, and the same is true for genomic selection [ 5].
The diversity of breeds has caused different problems: altered seasonality of the reproduction cycle from generation to generation in some cases and altered rusticity of the goats in others.
Key problems included altered diurnal mating rhythms of the laboratory-reared insects, resulting in asynchronous mating activity between the wild and released sterile populations, and low competitiveness of the radiation-sterilised mass-reared flies.
Once the team had collected survey data from its members and realized the magnitude of the problem, it altered its approach: Each person was given one workday a week when he or she didn't have to participate in the handoff call.
Long term effects of stress experienced in pregnancy has also been shown to increase risk of behavioral problems linked to altered the Hypothalamic Pituitary Adrenal Axis (HPA) activity [ 21].
