Exact(1)
Although the suggestion that the heteroduplex regions of crossover-associated and crossover-unassociated conversion events are formed differently may appear problematical, studies of meiotic recombination events in yeast provide a precedent.
Similar(59)
But it is problematical whether the study will provide definitive answers, and especially whether it will provide a clear enough idea of what the pre-Columbian ecosystem was like.
Although a more decisive role for the Con gress in limiting the power of one man to bring on the final Armageddon is problematical, it demands study and review in the context of current Asian policies.
However, case-control studies are problematical when there is a long prodromal disease phase.
Based on these results, the utility of most DpcCYC genes for use in phylogenetic studies would be problematical due to the presence of multiple putative copies, low amplification success for some genes (e.g. the DpcCYC3's), short sequences with a highly conserved TCP domain that yield low phylogenetic signal, and difficulties in aligning the intervening region.
Whether Austin can rein in the powerful economic and social forces at work is problematical.
If the extent of the scientific involvement of public pharmacology laboratories is strictly demarcated, financial support for nonsponsored studies by the pharmaceutical industry is problematical.
However, our figure is higher than the 3.5 7.3% incidence suggested in a systematic review [4]; this may be explained by the fact that pooling data from ADR studies with different designs can be problematical [23], [24] as illustrated by the widely differing estimates of ADR incidence determined in different studies in different populations (from 0.86% [25], to 37% [26]).
In non-randomised studies the case-mix adjustment is problematical but necessary [ 36].
However, since low frequency SNPs perform poorly in detection of linkage disequilibrium [ 29] this is unlikely to be problematical when identifying SNPs suitable for use in association mapping studies.
Both studies flagged the Emotional Functioning Scale as being potentially problematical.
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