Any of the miRNAs processed from the Sfmbt2 primary transcript would be imprinted, although testing this is problematical given the highly repetitive nature of the array itself, and the presence of other family members at other locations in the genome.
This type of restricted image use is problematical because experimental work on the nature of concepts suggests that they are best understood as encoding information about both the prototype of the conceptual category, and examples of variation around this prototype (Wisniewski 2002).
It may prove to be problematical.
Then there was that problematical list.
First, setting a benchmark often proves problematical.
But then came the evening's two problematical premieres.
Business heroes in the movies are rare, and often problematical.
Why revisit a problematical show like "St. Louis Woman"?
Jerome Robbins's "I'm Old Fashioned" is more problematical.
Bombing in the ruggedly mountainous countryside is problematical.
