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More than half (55.7 %) also found it very or fairly problematic to provide a long-term prognosis about patients' future work capacity.
A significantly higher percentage of the GPs (48.4%) also stated it very problematic to provide a long-term prognosis about future work capacity of patients on sick leave compared with the other physicians.
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Instituting rigorous due diligence reviews in this way serves both to identify problematic agents and to provide a legal defense in case of a stray violation.
From the hospital level, the infection control staff has to identify the most problematic units and to provide a feedback on the unit level in order to stimulate appropriate interventions on the unit level.
For example, extrinsic labelling of proteins can, in some cases, be problematic, requiring protein engineering to provide a suitable residue to which fluorescent dyes can be covalently coupled and it can be time-consuming to separate labelled and unlabelled proteins.
This arbitrary length threshold was used to provide a list of potentially problematic gene families which were then screened by BLAST analysis.
Withdrawal was problematic as GPs felt compelled to provide an alternative to benzodiazepines as well as applying a withdrawal strategy – something many had experienced failure with: "Lacking strategies for both successful taper and alternative treatment, physicians did not want to withhold a medication that provided ongoing relief to the patient" [ 6].
According to a recent study, physicians who worked in occupational health service and who had a well-established workplace policy regarding sickness certification matters were likely to find it less problematic to assess and provide a long-term prognosis of work capacity [ 45].
While Wolff's basic account of pleasure is problematic, he does provide a straightforward account of beauty.
This is problematic, since providing a referral slip to the parent or caretaker of a very ill child has been shown to be directly related to the degree of compliance with the referral.
Issues that rated highest as very or fairly problematic concerned providing a long-term prognosis about the future work capacity (68.5%) and assessment of a patient's work capacity (57.4%).
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com