Instituting rigorous due diligence reviews in this way serves both to identify problematic agents and to provide a legal defense in case of a stray violation.
From the hospital level, the infection control staff has to identify the most problematic units and to provide a feedback on the unit level in order to stimulate appropriate interventions on the unit level.
This helps to recognise problematic drug use, and to provide additional help as early as possible".
For example, extrinsic labelling of proteins can, in some cases, be problematic, requiring protein engineering to provide a suitable residue to which fluorescent dyes can be covalently coupled and it can be time-consuming to separate labelled and unlabelled proteins.
However, basing conclusions on these methods may be problematic as they fail to provide reliable estimates when there are directional evolutionary changes and can also be adversely affected when ancestral states fall outside the range of extant species [ 51, 52], as is expected to be the case for primate brain evolution [ 6].
It is worth noting at this point that open questions are problematic as well since having to provide free text increases the likelihood of participant dropouts.
In the context section (Context some examples) we would have, ideally, presented an approach and related results of in-depth empirical study, but because of the many 'stalemates', and related stakeholder reluctance to comment on the state of affairs, we will only refer to some Dutch examples of (problematic) district heating projects, so to provide some context to our quest.
These alterations are particularly problematic because physicians may hesitate to provide prophylaxis or aggressive treatment to pregnant women because of concerns about effects on the fetus.
The goal is to utilize results from this study to help social networks understand the potential problematic aspects of their intention to provide social support and to enhance the effectiveness of social support interventions.
