If indexing or space-group determination is problematic, it may be worthwhile to process the data assuming a triclinic P Bravais lattice and then do a careful search for valid unit cells with higher metric symmetry followed by thorough examination of systematic absences to choose the correct space group, which will necessitate reprocessing of the data.
Despite this flexibility, standardised elements of trial, such as participant recruitment processes, were perceived as problematic to local implementation processes.
On this view, it is problematic to define a process of political reconciliation in terms of forgiveness, because forgiving is a very private business that cannot be promoted as a policy.
Although attempts have been made to measure appropriateness of attendance in terms of a categorisation of the processes of care (whether patients have received treatments/investigations/referrals or are admitted, for example), it has proved problematic to achieve consensus about what processes of care make a visit appropriate.
At first glance the MyPlate image appears to eliminate many problematic sugary, processed foods, but when you actually click on the categories a host of unhealthy foods are revealed.
These structural issues (e.g. lack of specialist staff in the system) also contributed to the problematic process issues that some young adults reported experiencing, such as long waiting times to see healthcare professionals, suboptimal interactions with these professionals when young adults finally got to meet them and poor continuity of care.
In considering transcriptome k -mers, two cases arise that are particularly problematic for pseudogenes: processed pseudogenes with integrated splice junctions and duplicated pseudogenes that may have highly similar splice junctions to their parent genes.
To dispense with the problematic energy-minimization process prior to NMA while gaining computer efficiency, Tirion proposes a model to connect atom pairs with Hookean springs with a universal force constant γ (Tirion, 1996).
Even more problematic, a newly processed flow indicates that some amount of time has elapsed.
They cited a payroll business trade organization that said a two-month extension is problematic for electronically processed payrolls.
