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The role of residue Arg113 is somewhat problematic to evaluate from ELISA, because this mutation affected the reactivity of the anti-IL-11 antibodies.
In particular, it is known that leptin directly affects the pancreatic beta cells to decrease insulin secretion [59], but it is problematic to evaluate whether these changes are caused by leptin alone, by weight loss or both.
Studies of antifungal treatment in MC can be problematic to evaluate, particularly in the HIV-positive population.
For this reason it could be problematic to evaluate properly clinical pathways mainly because of the difficulty of keeping the intervention replicable and recognizable.
We also found aspects of timing (duration of morning stiffness, six weeks symptom duration) sometimes problematic to evaluate, as time perceptions are different compared to the Western world.
Apart from the discussed limitations of existing reference datasets often treated as gold standards, it would be problematic to evaluate the Lee and Lycett methods on the basis of the same gold standard data they received as input.
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Study aims were to assess the unique associations and interactive effects of implicit and explicit measures of drinking identity on problematic drinking, and to evaluate age and sex as potential moderators of the drinking identity problematic drinking relationship.
This is problematic when attempting to evaluate facilitation because unless clearly stated it leads to confusion surrounding what is being evaluated.
The BASC (Reynolds and Kamphaus 1998) is designed to evaluate problematic behaviors in children and adolescents 2.5 18 years of age.
PHEDRE is the first study which proposes to evaluate problematic use of EMONO and analgesics in the French SDC population.
The purpose of the study is to evaluate problematic use of analgesic drugs, received and/or taken at the hospital and at home.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com