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It is often problematic to distinguish between a new or residual defect on lung scintigraphy or helical CT.
Sibling psychiatric disorder was similarly defined as it proved problematic to distinguish as risk or outcome.
For examples, it has low sensitivity/specificity when tumor size is <10 mm; it can be problematic to distinguish disease progression from treatment effects, infection, or inflammatory changes; it does not reflect treatment-induced changes in tumor genotype.
It may be problematic to distinguish metaplasia of the gastric cardia from metaplasia of the BE and GEJ [ 10].
If this is the case, then single measures of medial temporal lobe activation alone would be problematic as a marker of disease activity, because there would be a period of pseudonormalization of activation that would be difficult to distinguish from normal activation.
Hard to distinguish from the master.
Its flaws are impossible to distinguish from its pleasures.
Some are harder to distinguish from their neighbors than others.
Occasionally called 2.75G to distinguish from GPRS.
Staff screening may be useful but is problematic as it needs to distinguish between transient carriage and longer-term colonisation.
(4:415) This is a claim he uses not only to distinguish assertoric from problematic imperatives, but also to argue for the imperfect duty of helping others.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com