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In the case of DMPs, varying healthcare demands between and within patients over time might make it problematic to design a good financial compensation system for DMPs.
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Subsequently, it is problematic to design accurate mathematical models for uncertain systems.
One of the reasons for using Euclidean and/or Manhattan distance is the relative ease of their implementation; in contrast, it is more problematic to design algorithms implementing actual road network distance in spatial analytical models.
Placebo-controlled trials using chemowafers, which have proven efficacy in high-grade gliomas, 20, 22 are problematic to design for single and oligometastatic brain cancer, for which there are multiple existing options (eg, surgery alone, SRS alone, resection plus SRS, resection plus WBRT) and deeply held biases.
Among the most problematic and persistent is the failure to design an interceptor missile that can distinguish between an actual enemy warhead and the debris, decoys and other countermeasures that an adversary would use to divert the interceptor from its target.
The location of the third and fourth turrets proved particularly problematic to the design of the class because the amidships turrets were not superfiring as in the subsequent s.
The identification of a primary study outcome measure around which to design the trial is problematic, since there is little evidence to indicate how health effects from such low-level exposure would be manifested.
A common assumption and perhaps quite problematic to crop insurance design is the reliance on a single weather station representing an area of 20 25 km radius (Gommes and Gobel 2013).
Introducing a deconvolution problematic in its design, a "virtual feed forward" based on estimation has been introduced to balance the external disturbances.
The results suggest that even with carefully designed tasks, it is problematic to directly compare scores from initial tests and retests.
The problematic toilet was designed to purify urine into drinkable water.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com