Sentence examples for problematic to accurately from inspiring English sources

To date, it has been problematic to accurately quantify multiple nucleic acid sequences, representing microbial targets, in multi-target mixtures using oligonucleotide microarrays, primarily due to nonspecific target binding (i.e., cross-hybridization).

Speaking constructs, as relatively abstract entities, present themselves as problematic to accurately define, which has led to the IELTS language testing community assigning the validation of the construct as primarily an ongoing research activity.

Currently, it is problematic to accurately equate PA into units of energy expenditure (EE), as EE varies significantly from person to person depending on body mass, type of physical disability and efficiency of movement.

However, the relationships among the neural activity recorded by these arrays are often highly complex making it problematic to accurately quantify a network's structural information and then relate that structure to its function.

Although the response of different cell types to optogenetic manipulation is problematic to accurately predict, our results implicate a major involvement of both sensory and interneuron components of the larval CNS rather than a contribution by motoneurons (for details, see Table S2).

"Given the health end points including cancer, cardiovascular disease, neurological, immunological, and developmental disorders, and allergic airway disease including asthma, it will be extremely problematic to accurately assess the true impact of expanded goods movement in coming decades on the health of exposed populations".

Since the SIA trees include more sequences than the masked trees, and the additional sequences might be among the most problematic to place accurately in the tree due to their reduced length, a fairer comparison would be to compute stQD for a pruned SIA tree having the same set of sequences as the masked tree.

Overall, the total income from intellectual property is a useful indicator, but currently it is problematic to attribute it accurately between multiple departments and it represents only a small percentage compared to research expenditure.

In this circumstance, it can be problematic for software engineers to accurately predict the possible problems that may exist in implementations of MSC specifications and to trace back to the design problems in MSC specifications from the observed problems of an implementation.

Even when staffed by well-trained physicians, the accuracy of suspected diagnoses during resuscitation was problematic; future studies are required to accurately predict which groups of patients are most likely to benefit from HEMS.

The BRCA1 gene contains multiple mononucleotide repeats, for which it is challenging to accurately detect 1 bp indels; these regions are the most problematic to detect for all current methods [ 36, 40, 41].