Sentence examples for problematic targets from inspiring English sources

For such problematic targets, a number of random library-based strategies have been developed that generate large collections of randomly truncated or fragmented constructs and couple these to a screen or selection process to identify rare soluble clones [23] [28] reviewed in [29] [31].

These targets are usually not applicable for in vivo production of monoclonal antibodies in mice; however, highly affine aptamers have been selected against some of these problematic targets [ 5].

Mr. Noriega surrendered after a 10-day standoff with American forces, but he had taken refuge in the Vatican Embassy in Panama, obviously a much more problematic target than the house in Mosul.

Importantly, the functional TRPV1 in keratinocytes could have made them a problematic target seemingly able to generate unwanted side effects and prevent future use of either transdermal capsaicin or RTX.

It remains possible that one or more of the problematic genomic targets noted above could be useful for studies of chlorophytan barcoding.

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We asked them to review the full ranked list of recommendations from Stage 2, select between five and 10 recommendations that they considered would best meet our aims and highlight any they considered problematic to target.

To begin with, one needs to get clear what Kvanvig has in mind when he talks of understanding, since many commentators have found the conception of understanding that he targets problematic.

Retention in trials involving behaviour change was also thought to be problematic if change targets were not achieved by participants.

There is preliminary evidence that cognitive-emotional training directly targets problematic biases in MDD and is able to improve them, with concomitant improvements in depressive symptomatology.[ 50] These intriguing preliminary results suggest that nonpharmacological treatments may be able to target problematic cognitive biases as well as, if not better than, medication.

In a rare interview in May, co-founder and CEO Ilja Terebin said the site's "main public is teenagers, and it is often a problematic and aggressive target market.