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Many climate scientists see increased emissions of methane, a potent warming gas, as a highly problematic side effect of the recent gas boom.
Prior to this study, it was thought that the problematic side effect of diarrhoea associated with each of irinotecan, 5-FU and radiation would cause severe toxicity should the agents be combined, rendering the regimen too toxic for routine use.
Therefore, therapeutic strategies focusing on non-specific, systemic blockade of TGFβ ligand-receptor interactions may have a problematic side effect profile considering the complex function of TGFβ in vivo [ 41].
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GlaxoSmithKline took the drug all the way through Phase II clinical trials in humans, successfully demonstrating that it lowered cholesterol levels without any problematic side effects.
But the independent research group led by Arnold Monto, professor of epidemiology at the University of Michigan School of Public Health in the US, and Stuart Pocock, professor of medical statistics at the London School of Hygiene and Tropical Medicine, found Tamiflu had problematic side effects.
It was originally sold as an over-the-counter cough suppressant that didn't have problematic side effects, like addiction (the irony) - while alternative treatments morphine and codeine did.
If the unmapped preconditions of mapping remain unconsidered, this can lead to problematic side effects.
Attempts have been made to disrupt cue-memory reconsolidation or to strengthen extinction learning, but these efforts have often relied on pharmacological agents that either are not approved for human use or cause problematic side effects.
The problematic side effects that can occur during SIT with allergen extracts led to the search for safer alternatives, such as recombinant hypoallergenic proteins with reduced allergenic potential and preserved T-cell immunogenicity.
The ubiquitous use of smartphones has not only led to unprecedented levels of connectivity, but also raised the question about potentially problematic side effects such as phone-use while driving or phone-caused inattention in work or private settings.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com