Stigma and exclusion are most problematic in settings where epidemics are still relatively concentrated, so children and their parents can quickly become social outcasts.
Serious gaps in the implementation of needle/syringe programs are well-documented and especially problematic in settings with weak rule of law [ 26- 29].
This may be particularly problematic in settings with a high rate of initial default and especially among HIV-infected patients with advanced immunodeficiency in whom delays in diagnosis may be associated with considerable mortality risk [ 11].
The masking of AKI severity by volume expansion may be especially problematic in settings where the sCr is rising relatively slowly owing either to lower creatinine generation (e.g., as might be expected in the elderly or patients with less muscle bulk) or to more modest overall injury.
However, while online self-completion of TTO tasks with no interviewer assistance may be problematic, alternative settings, such as a group interview session where respondents self-complete computer-based surveys with interviewers on hand to provide instruction and assistance as required, offer a potentially attractive compromise.
NEC says the chip is able to identify colors that are "problematic" in those settings, i.e. beige or yellow, and boosts contrast.
Introduction: Pain and anxiety are distressing for patients in intensive care units (ICUs) and effective pain and anxiety assessment and management are problematic in ICU settings.
Bacterial biofilms are problematic in industrial settings, where they contribute to biofouling [1] and in human health, where they contribute directly to antibiotic resistant infections [2], [3].
This might be problematic in clinical settings, because there is only a relatively small window between the size at which the tumor becomes detectable (about 1010 cells) and the size at which it can induce mortality (around 1013 cells).Tumor growth saturation at lower levels introduces a parameter region in which only the tumor control outcome is possible.
Pressure ulcers (PUs) are problematic across healthcare settings throughout the world [ 3, 4].
This situation is particularly problematic in PC settings because advanced cancer patients are prone to a faster rate of clinical deterioration [ 4].
