Comparisons with other published values for pQCT measured bone parameters are problematic as methods, scan sites and threshold settings vary greatly.
However, it would be problematic to only scan the small joints of patients in cohorts where RA presents with predominant residual large joint synovitis [ 94].
In accordance with several other groups, we found 177Lu-DOTATATE PRRT dosimetry based only on 2-D scanning problematic due to inherent difficulties of delineating healthy organ uptake from tumours and physiological uptake as in the bowel [12, 28, 29].
Multiple hot/cold spots would seem to be problematic when using the scan statistic, since it uses a likelihood function from a model based on a single hot or cold spot only.
Although attempting to locate sulcal landmarks on an averaged MRI scan is problematic, the medial PFC activity observed in the present data does appear to be in the vicinity of the participants' average paracingulate sulcus location (most clearly illustrated in the right panel of Fig. 3c).
Furthermore, during import, datasets are scanned for problematic molecules or features of molecules like Pan Assay Interference Compounds (PAINS), which may disturb the assay setup or unspecifically bind to diverse proteins [26].
The low specificity of the visual PET scan assessment is problematic, but this could be significantly increased by improvements in the spatial resolution of tomographs as well as by the use of appropriate training programmes for raters, and by the development of semiautomatic or automatic quantifications method or software.
The production of removable dentures from intraoral scans has been problematic.
The complexity of the LC architecture and the need to measure minute focal changes to detect disease progression make low scanning resolution especially problematic.
In general this is not problematic, since the number of scans acquired for reach participant is very large in comparison with the number of experimental conditions of interested.
While you're going about your daily life, your phone could be constantly scanning for hints of problematic behavioral changes, alerting your doctor when things veer off-course.
