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As recognized by the authors, the RMSD is a problematic quantity when detecting local movements, as the RMSD is a global quantity that measures an average over all residues/atoms considered.
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Genes encoding enzymes with the same function (isozymes) can also be problematic: often the quantity of real interest for a particular reaction is the net change in flux or flux capacity for that reaction, thus multiple gene changes related to a single reaction should be accounted for together rather than as separate nodes in a graph representation of metabolism.
The agency Fitch also predicted stability for the sector, although it said profitability would be low and there were risks due to the large quantity of "problematic assets".
This is problematic, because a given quantity of proton motive force driving chemiosmosis is generated by a set number of electrons transferred.
If the subject under review was more widely researched, synthesising and translating the synthesis may be more problematic due to the quantity of data and potential contradictions in the findings.
Problematic is not only the quantity but also the regional dispersal of energy crops because of cumulating effects, which cannot be adequately displayed for none of the criteria using the current methodology.
Limiting compatibility to a single device (even one that's probably going to sell in ridiculous quantities) seems awfully problematic given Samsung's generally slow record for software updates.
However, as other recent microbiome studies have pointed out, contaminants become increasingly important and problematic at low target DNA quantities [ 28– 31].
This time point was chosen because quality isolation of RNA from newly blood fed mosquitoes can be problematic, and collection of reasonable quantities of hemocytes by perfusion before the peritrophic matrix forms (~18 hours), is extraordinarily difficult.
However, remediation of COPR related Cr VI) has proven problematic, due to the large quantities of materials involved, and the adverse alkaline pH that often impacts on the efficiency of conventional chemical treatments [32,41,42].
Despite growing popularity of experience sampling methodology (ESM) for evaluations of state-based components of body image, there have been concerns that the frequent repeated measurement might encourage problematic responding resulting in low data quantity and/or quality.
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