The most problematic phase of Russia's identity quest culminated in outright confrontation with the West during the deadly Georgia conflict of August 2008.
In Phase 4, the author altered the Japanese expression of the parts found to be problematic in Phase 3 with reference to any alternatives rejected in Phase 1.
Using the same problematic two-phase design, a second British study [ 22] included 48 7–17 years olds looked after by a local authority and interviewed 22 CBCL high scorers with the K-SADS-PL [ 26].The authors reported that 21 (44%% of the total sample) had a definite, probable or resolving DSM-IV diagnosis.
An unduly high rate of false negative results could be especially problematic in early phases of drug development where only one or two chances exist to make the correct decision regarding the efficacy of a drug.
Direct application of methods for estimating breeding values in crossbreeding situation can be problematic when association phase between markers and QTL differ in the two parental lines, which is increasingly likely when the distance between markers and QTL increases.
On a related note, and more generally, the formal definition of a critical system as one operating at, or near, a second-order (continuous) phase transition is problematic since the concept of phase transition applies to systems with infinite degrees of freedom [22].
For business students only Low feedback and Exhaustion differed by stage, and they were less problematic in the advanced phase; while medical students in the clinical stage reported more Worries about future endurance/capacity and Role conflict.
Such complementary tools may limit and remove the most problematic candidates in early phases or allow medicinal chemistry departments to optimize the structure early on.
However, ELISA methods are often matrix- and species-dependent, and the method development is often time-consuming and costly, which is especially problematic in the early phases of drug discovery and development.
The prospective identification of study participants in research in the dying phase is problematic as there are no specific criteria for identifying the dying phase [ 2].
