This last core course will enable students to fill in the holes in their manuscripts, working closely with an instructor who will help identify missing sections, guide the redrafting of chapters that previous workshops have shown to be problematic, perform line editing, or take on any other activities the instructor and student feel will best advance the completion of the manuscript.
It should be noted that the absence of a reliable source for road crashes [14] is problematic when performing such evaluations.
Side effects of 5-FU, such as diarrhea and weight loss, are problematic in performing chemotherapeutic tests with animal models.
Still, it seems to be problematic to perform large scale of analysis on FFPE because of the high CTs and limited concentration of extracts [ 14, 15].
A noted ceiling effect on postoperative Oxford scores (ie, potentially problematic when performing regression modelling) led us to review our data.
In vitro cytotoxicity test has the advantage of easy control of experimental factors that are often problematic when performing experiments in vivo.
Most diagnostic labs have already invested in the optimization of PCR assays for the genomic regions of interest; it is therefore problematic to perform this optimization again in order to switch sequencing platforms.
These issues may be particularly problematic for performing two measurements in the 1st year postpartum in new mothers, a design feature that was integral to the novel demonstration of early deterioration of β-cell function.
Tympanocentesis-based efficacy studies, even at the population level, would at least help specify how much of an overall decrease is limited to target pathogens/serotypes, but it remains unusual and ethically problematic to perform routinely, and determining vaccine effectiveness against individual serotypes necessitates large sample sizes.
Polymorphic chromosomal rearrangements can be problematic when performing association studies (one of the main tools when addressing the molecular basis of phenotypic variation), because they may create linkage disequilibrium over large physical distances, and thus, in principle it is best to choose a species without chromosomal polymorphism.
