As soon as food safety measures address one problematic infection pathway, the microbes appear somewhere they have never been detected before.
This is especially problematic for signaling pathways, because signaling pathways are considered to be more global (from membrane to cytoplasm and to nucleus) rather than local protein interactions.
Efficiently targeting pathways is problematic, because it is unclear whether we should identify pathway targets by level of expression or by their location in the pathway (e.g., upstream elements).
Incorporation of important mineral elements into soil by fertilizers could be problematic due to their pathway in soil.
With the caveat that identifying a CheY homologue as being involved in a chemotaxis pathway is problematic, models of chemotaxis which treat CheY differently to the other Che proteins may therefore be most appropriate.
Miller et al. (2016) found that women's pathways to problematic drug use and crime are strongly associated with romantic partner relationships.
An impediment to progress in this field has been that the mitochondrial Ca2+ transport proteins were not purified or cloned, and that use of the inhibitors of these pathways is problematic in living cells.
Emetine was used to block the pathway, but was problematic as emetine induces a stress response that results in the upregulation of additional transcripts.
Traditional nucleosides with an available 5′-hydroxyl that can enter nucleoside metabolic pathways, however, are problematic as biological probes due to their propensity to enter numerous nucleoside metabolic pathways and cause general toxicity through inhibition of DNA and RNA metabolism.
identifying hydrogeological problematic areas, and possible impact pathways, at an early stage, and proposing measures for ongoing monitoring, reducing the hazard potential of the fracking fluid potentially used.
