Really, the large lag on this data is highly problematic in time of crisis.The European Central Bank is no doubt sick of the nagging by now.
Instability of CFP fluorescence can also be problematic for time-resolved FRET experiments.
On the contrary, the recombinant fusion of many different chimeras could be problematic in terms of time, different levels of expression, or even impossibility to synthesize the protein.
Time pressures related to grant applications and project-specific time-lines were also highlighted as problematic, including lack of time to take account for public members' illness and/or work commitments, the lack of realistic timeframes for reviews and, not least, the lack of time needed to develop and nurture research team relationships.
Such systems can address oral proficiency, one of the most problematic skills in terms of time investments and costs, and are seriously being considered as a viable alternative to teacher-fronted lessons.
This is in contrast to other definitions which use a fixed age, for example, age 65; use of a fixed age is problematic over long periods of time.
However, a distinction between brain-metastasis-related, extracranial-tumour-related and treatment-related impairment would probably have been similarly problematic at other points of time.
Frequency of possibly problematic situations or lack of time, reasons for sickness certifying unnecessarily long, experience of difficulties in contacts with sickness insurance offices, and severity of experienced problems.
Phylogenetic analysis of polyploid species has typically been problematic, requiring large amounts of time and effort to sequence multiple gene copies in sufficient individuals using traditional Sanger sequencing and bacterial cloning [ 13, 16, 18].
The UK National Treatment Outcome Study (NTORS) for example, was able to follow-up 72% of its initial cohort after one year [ 23] and follow-up becomes increasingly problematic over longer periods of time.
But Chrysler's embrace of its German parentage might be problematic at a time of increased patriotic fervor.
