Both the BASC and BRIEF include standard validity scales to identify problematic observations.
For quality control, we checked data in all cities for any unreasonable temperature values [temperatures > 50°C or < –40°C (Kloog et al. 2012)] and found no problematic observations.
This mismatch between scales of investigation and scales of management is problematic because observations of many phenomena depend on the scale at which those observations are made.
Most problematic is the observation that the activity due to tight pterin binding is also retained when the enzyme is incubated overnight with an excess of BH4.
This dedication of attention necessarily interferes with the process to be observed if the process is a mental one; therefore, he says, inner observation is problematic as a scientific psychological method.
Anscombe's discussion of her claim is rich and suggestive, but her conception of 'knowledge through observation' is problematic.
Studying the effects of mechanical strain on the structure of 10FNIII is problematic because the direct observation of short-lived, partially unfolded states is difficult to achieve experimentally.
This observation is problematic when detection of a specific RNA strand is needed.
Since direct observation is problematic, the understanding of such pyroclastic density currents (PDCs) represents a challenge whose solution is mainly based on analysis of deposit characteristics.
