This potentially problematic recruitment mechanism is modulated by a ubiquitin-dependent mechanism to avoid the disruption of silencing.
The first is overkill: faced with the seemingly simple challenge of segregating nascent transcripts from DNA, why would evolution have devised as elaborate and seemingly problematic a mechanism as the spliceosomal system, rather than a simpler and presumably more efficient TREX-like transcript-coating mechanism?
One difficulty she points to is the constant presence of cameras, which Patridge says led to a problematic coping mechanism.
The problematic tilting mechanism was not used during winter 2010 2011 and the time benefit of the tilting was not taken into account in timetables of winter 2011 2012.
However, the dichotic listening task has some features making inference about the neurophysiological attentional mechanisms problematic, for instance, because of interaction between left and right side of the brain during binaural vs. monaural listening (see, e.g., [26]).
However, the hypothesis of position invariance is biologically problematic because neural mechanisms vary profoundly with visual field eccentricity (see Discussion).
Furthermore, primary neurons do not provide a uniform population either in terms of cell types or differentiation state, rendering their use for identification of direct neurotoxic mechanisms problematic.
And when the sales figures drop, the labels will probably conclude that online piracy (not draconian copy-protection) is to fault, and I wouldn't be surprised if they introduced even more problematic copy-protection mechanisms as a result.
The latter issue is particularly problematic for researchers studying mechanisms of evolution of reproductive isolation between populations in sympatry [ 21].
