Sentence examples for problematic marker from inspiring English sources
To determine the effect of removing this potentially problematic marker from the RM Y-STR panel, the entire dataset was additionally analyzed without DYF403S1a+b.
There might be several reasons for such considerable changes, calling for careful analysis followed by corresponding decision making (e.g. deleting the problematic marker from one or several datasets).
Since it can be extremely difficult to determine who exactly has the erroneous genotype within small families [70], we set genotypes of problematic markers to missing for every individual within each family containing a Mendelian inconsistency; this needed to be done for only one SNP (rs859705 in part 3) in one family.
These can be used to identify problematic markers and studies during meta-analysis.
Nonetheless, data analysis filters inherent in the software can eliminate, at least partly, these problematic markers.
At several points, a consensus map was produced using MergeMap [ 32], which also flags problematic markers for review.
In case of more than one round of map building, we used the second round without allowing the programme to force any problematic markers into the map.
Many of them had low minor allele frequencies or failed Hardy-Weinberg equilibrium (HWE), but were included in order to test the data filters inherent in HFCC, which are meant to eliminate, at least partially, these problematic markers.
We did not use the ability of the software to force problematic markers on to the map and used the map resulting after the second round of map building.
The map data resulting from the initial mapping analysis were manually curated to identify and remove problematic markers that caused elevated numbers of double crossovers and expansions in the length of the linkage group.
Raw data for problematic markers were reviewed using BeadStudio and then either the marker was discarded entirely if any ambiguity in data calling could not be resolved or individual genotype calls were modified if it was plainly evident that such adjustments were warranted.
