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In this case the most problematic issue is sewage sludge ash contamination with heavy metals.
Mark Ashley, the general manager for commercial development at Ninti One, the commercial arm of the government's feral camel management plan, says that the most problematic issue is transport.
The more problematic issue is how to regulate imports of milk and meat products — and large amounts of eggs, semen and embryos — from cloned animals raised in countries where the technique is used, like the United States, Argentina and Brazil.
A second potentially problematic issue is that the new system changed many different variables and the current study has only estimated the overall net effect of these changes.
Another more problematic issue is that many seismologists are convinced, after decades of scrutiny, that the crust doesn't undergo major changes before it ruptures that would produce precursor signals.
However, one problematic issue is that we here deal with the strong nonlinear term u m in our equation (1.3), making the proof of several required nonlinear estimates somewhat delicate.
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The most problematic issue was that many of our API clients did not respect the DNS record time to live (TTL) values being broadcast by Route 53.
A second problematic issue was establishing how to deal with the adjectives.
Then on Nov. 12, I received an email that the problematic issue was my place of birth Iran!
Another problematic issue was how to relate to patients who were ventilated in wards but were not presented at any time to an ICU staff.
One of the most problematic issues is the lack of power to compute the extinction rate (in our case) compared with the net diversification rate, up to the point that some authors consider that extinction rates should not be estimated at all from phylogenies (Rabosky 2010).
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com